We study the cellular mechanisms of mitochondrial DNA integrity and inheritance.

The legacy of endosymbiosis

Within each of our cells, the genetic control of metabolism is split between the nuclear genome and a multitude of small, circular mitochondrial genomes. The co-inheritance and -regulation of these genomes is required for aerobic life. Mitochondrial DNA defects cause hereditary metabolic diseases that impact tissues with high energy demand, such as the brain, muscle and heart, and are also linked to cancer and the innate immune response. We aim to reveal the cellular mechanisms that ensure mitochondrial DNA integrity and inheritance in metazoans, using quantitative imaging, genetics and systems biology approaches.

 
 

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We are grateful for the support of current and previous sponsors